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historically, the small numbers of children presenting with gender dysphoria were primarily prepubescent males. in recent years, there has been a sharp increase in referrals of adolescents, and particularly adolescent females, to gender clinics. many do not have a significant history of childhood gender dysphoria and a number suffer from comorbid mental health issues and neurodevelopmental conditions such as autism (asd) and attention-deficit/hyperactivity disorder (adhd). the reasons for these changes are understudied and remain poorly understood. childhood-onset gender dysphoria has been shown to have a high rate of natural resolution, with 61-98% of children reidentifying with their biological sex during puberty. the research into the course of gender dysphoria desistance among the cohort presenting with adolescent-onset gender dysphoria is still in its infancy, due to the novelty of this presentation. however, recent research from the uk clinic population suggests that 10-12% of youth may be detransitioning within 16 months to 5 years of initiating medical interventions, with an additional 20-22% discontinuing treatments for a range of reasons. the researchers noted that the detransition rate found in the recently-presenting population raises critical questions about the phenomenon of "overdiagnosis, overtreatment, or iatrogenic harm as found in other medical fields."

one of us is an european citizens’ initiative launched to demand the community institutions to guarantee the protection of human beings since conception.